Bevacizumab in epithelial ovarian cancer treatment, efficiency and risks
نویسندگان
چکیده
منابع مشابه
Bevacizumab in the treatment of ovarian cancer
Despite advances in surgical cytoreduction and cytotoxic chemotherapy, ovarian cancer continues to be the leading cause of death in women with gynecologic malignancy. Our understanding of the treatment of ovarian cancer was revolutionized with the discovery of platinum- and taxane-based adjuvant chemotherapy regimens. Since that time however, overall survival has been stable. Given the above, a...
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Objective: The goal of this study is to evaluate the efficacy of intraperitoneal (JP) cisplatin as consolidation treatment, in epithelial ovarian cancer patients with pathologically negative surgical reassessment, following first-line platinum-based chemotherapy. Methods: This study included 22 patients with FIGO stage (IIc- IV) epithelial ovarian cancer (EOC) which had no evidence of disea...
متن کاملAdvances in treatment of epithelial ovarian cancer.
Since most cases of epithelial ovarian cancer are advanced at diagnosis, this disease is one of the most lethal malignancies of the female genital tract. In recent years, aggressive cytoreductive surgery and chemotherapy have been employed in an attempt to improve the survival rate in patients with epithelial ovarian cancer. Introduction of platinum anticancer drugs increased survival rate, and...
متن کاملCritical appraisal of bevacizumab in the treatment of ovarian cancer
Bevacizumab is the first molecular-targeted agent to be used for the treatment of ovarian cancer. Bevacizumab is a humanized monoclonal antibody targeting vascular endothelial growth factor. Two randomized Phase III trials evaluated the combination of bevacizumab plus standard cytotoxic chemotherapy for first-line treatment of advanced ovarian cancer. Additional Phase III trials evaluated bevac...
متن کاملSystematic evaluation of bevacizumab in recurrent ovarian cancer treatment.
PURPOSE This study aimed to evaluate the efficacy and safety of bevacizumab in the treatment of recurrent ovarian cancer. METHODS The Cochrane Library, MEDLINE, and EMBASE were searched. Data regarding the use of bevacizumab in recurrent ovarian cancer were collected from randomized controlled trials (RCTs). Data were evaluated with the Cochrane systematic method, and statistical analysis was...
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ژورنال
عنوان ژورنال: Onkologie
سال: 2018
ISSN: 1802-4475,1803-5345
DOI: 10.36290/xon.2018.036